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START TREATMENT IN 1 DAY WITH ARISTADA INITIO AND ARISTADA

  • ARISTADA INITIO® (aripiprazole lauroxil) reduces oral aripiprazole supplementation to 1 day1
  • ARISTADA INITIO® (aripiprazole lauroxil) is only to be used as a single dose to initiate ARISTADA® (aripiprazole lauroxil) treatment or as a single dose to reinitiate ARISTADA treatment following a missed dose of ARISTADA. ARISTADA INITIO is not intended for repeated dosing‭‭1,2
ARISTADA INITIO (aripiprazole lauroxil)

“I was glad they were able to start my treatment in the hospital.”

- Jordan

Both steps for initiating ARISTADA treatment can be completed in 1 day1,2

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DAY 1
STEP 1

After establishing tolerability with oral aripiprazole, give patients a one-time ARISTADA INITIO injection and a single 30 mg dose of oral aripiprazole1,2

1 ARISTADA INITIO DOSE AND A SINGLE 30 MG DOSE OF ORAL ARIPIPRAZOLE

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DAY 1
STEP 2

Select one ARISTADA dose and give on the same day or up to 10 days later if desired1,2

FIRST ARISTADA DOSE

Please see the dosing considerations for more information about dosing ARISTADA.

Important dosing considerations for ARISTADA INITIO

  • ARISTADA INITIO and ARISTADA are not interchangeable because of differing pharmacokinetic profiles1,2
  • ARISTADA INITIO and ARISTADA are only to be administered as an intramuscular injection by a healthcare professional1,2
  • For patients who have never taken aripiprazole, establish tolerability with oral aripiprazole prior to initiating ARISTADA or ARISTADA INITIO‭1,2
  • ARISTADA INITIO can be administered in the deltoid or gluteal muscle.1 ARISTADA can be administered in the gluteal (all doses) or deltoid muscle (441 mg dose only). Avoid injecting both ARISTADA and ARISTADA INITIO concomitantly into the same deltoid or gluteal muscle1,2
  • If not starting ARISTADA with ARISTADA INITIO, administer 21 consecutive days of oral aripiprazole with the first ARISTADA injection2
  • ARISTADA INITIO is only available at a single strength as a single-dose pre-filled syringe, so dosage adjustments are not possible. Avoid use in patients who are known CYP2D6 poor metabolizers or taking strong CYP3A4 inhibitors, strong CYP2D6 inhibitors, or strong CYP3A4 inducers, antihypertensive drugs and benzodiazepines1

MEAN HALF-LIFE OF DAY-1 DOSING COMPONENTS

  • With the addition of a single intramuscular injection of ARISTADA INITIO and 30 mg oral aripiprazole at the time of the first ARISTADA dose, aripiprazole concentrations reach relevant levels within 4 days1
  • With a single dose of ARISTADA, aripiprazole concentrations appear in the systemic circulation starting from 5 to 6 days and continue to be released for an additional 36 days2

In a pharmacokinetic (PK) study, one ARISTADA INITIO injection and a single 30 mg dose of oral aripiprazole with ARISTADA resulted in aripiprazole concentration levels comparable to when ARISTADA is initiated with 21 days of oral aripiprazole.‭1

Learn more about the clinical studies, including additional data, supporting the efficacy and safety of ARISTADA2-4

CLINICAL OVERVIEW
References: 1. ARISTADA INITIO [package insert]. Waltham, MA: Alkermes, Inc; 2019. 2. ARISTADA [package insert]. Waltham, MA: Alkermes, Inc; 2019. 3. Nasrallah HA, Aquila R, Du Y, Stanford AD, Claxton A, Weiden PJ. Long-term safety and tolerability of aripiprazole lauroxil in patients with schizophrenia. CNS Spectr. 2018:1-9. 4. Data on file. Alkermes, Inc.